The Sullivan lab uses the Drosophila embryo as a model system to investigate the mechanisms that drive furrow invagination during cytokinesis. Through a combination of cellular and molecular genetic approaches, the Sullivan group has showed that furrow formation requires coordinated cell cycle regulated and endocytic-based vesicle recruitment. These studies have also identified a new role for cell cycle checkpoints in coordinating the nuclear cycle with cytokinesis. More recently, the lab has applied these approaches toward understanding the mechanisms by which the widespread intracellular insect pathogen, Wolbachia, influences host nuclear and cytoplasmic cell cycles.
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