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Benoit Miotto
Responsable de l'équipe, Epigénétique, Réplication de l'ADN et Cancer
Institution:
USPC - SET - SVS
Summary
Published articles Show More
Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers
Published in Proceedings of the National Academy of Sciences
The origin recognition complex (ORC) binds sites from which DNA replication is initiated. We address ORC binding selectivity in vivo by mapping ∼52,000 ORC2 binding sites throughout the human genome. The ORC binding profile is broader than those of sequence-specific transcription factors, suggesting that ORC is not bound or recruited to specific DN...
Direct non transcriptional role of NF-Y in DNA replication
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Published in Acta Biochimica et Biophysica Sinica
NF-Y is a heterotrimeric transcription factor, which plays a pioneer role in the transcriptional control of promoters containing the CCAAT-box, among which genes involved in cell cycle regulation, apoptosis and DNA damage response. The knock-down of the sequence-specific subunit NF-YA triggers defects in S-phase progression, which lead to apoptotic...
Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activi...
Published in Oncotarget
Adult T-cell leukemia (ATL) is an often fatal malignancy caused by infection with the complex retrovirus, human T-cell Leukemia Virus, type 1 (HTLV-1). In ATL patient samples, the tumor suppressor, p53, is infrequently mutated; however, it has been shown to be inactivated by the viral protein, Tax. Here, we show that another HTLV-1 protein, HBZ, re...
Theses Show More
Experience
Responsable de l'équipe Since 2015
université Paris Descartes
Epigénétique, Réplication de l'ADN et Cancer; Développement, Reproduction, Cancer (DRC); UMR 8104 / UMR_S1016, Institut Cochin; Faculté de Médecine
