Athanassia Sotiropoulos

Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidenc...

Published in AJP Endocrinology and Metabolism

Citrulline (CIT) is an endogenous amino acid produced by the intestine. Recent literature has consistently shown CIT to be an activator of muscle protein synthesis (MPS). However, the underlying mechanism is still unknown. Our working hypothesis was that CIT might regulate muscle homeostasis directly through the mTORC1/PI3K/MAPK pathways. Because C...

Nuclear actin and myocardin-related transcription factors control disuse muscle atrophy through regulation of Srf activi...

Published in Journal of Cell Science

Skeletal muscle atrophy is a debilitating process that is associated with a wide variety of conditions including inactivity, disease and aging. Here, we demonstrate that the actin, myocardin-related transcription factors and serum response factor (actin-Mrtf-Srf) pathway is specifically downregulated in the muscle atrophy that is induced through di...

Role of Serum Response Factor as in the Mechanotransduction of the Muscle Cell

Published in Biophysical Journal

Rôle du facteur de transcription Srf au cours de l'atrophie du muscle squelettique et dans les cellules satellites

Le muscle squelettique adulte est un tissu possédant la capacité fondamentale d’adapter sa taille à la demande fonctionnelle : il peut s’atrophier ou s’hypertrophier en réponse à une variation de la charge mécanique qui lui est appliquée. A l’heure actuelle, les facteurs impliqués dans la plasticité musculaire demeurent méconnus. D’une part, grâce ...