Armelle Leturque

Intestinal invalidation of the glucose transporter GLUT2 delays tissue distribution of glucose and reveals an unexpected...

Published in Molecular Metabolism

Objective Intestinal glucose absorption is orchestrated by specialized glucose transporters such as SGLT1 and GLUT2. However, the role of GLUT2 in the regulation of glucose absorption remains to be fully elucidated. Methods We wanted to evaluate the role of GLUT2 on glucose absorption and glucose homeostasis after intestinal-specific deletion ...

Alteration of intestinal permeability: the missing link between gut microbiota modifications and inflammation in obesity...

Published in médecine/sciences

The increasing incidence of obesity and associated metabolic complications is a worldwide public health issue. The role of the gut in the pathophysiology of obesity, with an important part for microbiota, is becoming obvious. In rodent models of diet-induced obesity, the modifications of gut microbiota are associated with an alteration of the intes...

Short Term Palmitate Supply Impairs Intestinal Insulin Signaling via Ceramide Production

Published in Journal of Biological Chemistry

The worldwide prevalence of metabolic diseases is increasing, and there are global recommendations to limit consumption of certain nutrients, especially saturated lipids. Insulin resistance, a common trait occurring in obesity and type 2 diabetes, is associated with intestinal lipoprotein overproduction. However, the mechanisms by which the intesti...

Invalidation de la détection des sucres par le transporteur-détecteur GLUT2 (impacts sur les homéostasies glucidique et ...

La détection des sucres est le mécanisme par lequel les concentrations de sucres sont converties en signaux intracellulaires permettant aux cellules d adapter leur équipement protéique et leurs fonctions. Nous étudions les mécanismes de détection des sucres par GLUT2. Par sa fonction de transporteur de glucose à l intérieur de la cellule, GLUT2 par...

Kinase cascades in the regulation of glucose homeostasis

FR

Implication de la karyopherine alpha 2 dans la transduction du signal glucose dans les cellules hépatiques

FR