Bioinformatics, Biostatistics
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Anthoula Gaigneaux
bioinformatician
Discipline:
Biology
Summary
Published articles Show More
Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal c...
...Published in Cancer Letters
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...
Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma
Published in Oncogene
A limiting factor in the therapeutic outcome of children with high-risk neuroblastoma is the intrinsic and acquired resistance to common chemotherapeutic treatments. Here we investigated the molecular mechanisms by which the hemisynthetic cardiac glycoside UNBS1450 overcomes this limitation and induces differential cell death modalities in both neu...
Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450
Published in Cell Death and Disease
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na + /K +)-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis pr...
Experience
bioinformatician Since October 2010
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC) (Luxembourg LU)
bioinformatician
