Anne-Ruxandra Carvunis
Postdoctoral Fellow
Institution:
Ideker Lab
La Jolla, CA, United States
https://www.mysciencework.com/profile/anne.ruxandra.carvunis
Summary
Published articles Show More
Integrative approaches for finding modular structure in biological networks.
Published in Nature Reviews Genetics
A central goal of systems biology is to elucidate the structural and functional architecture of the cell. To this end, large and complex networks of molecular interactions are being rapidly generated for humans and model organisms. A recent focus of bioinformatics research has been to integrate these networks with each other and with diverse molecu...
Siri of the cell: what biology could learn from the iPhone.
Published in Cell
Modern genomics is very efficient at mapping genes and gene networks, but how to transform these maps into predictive models of the cell remains unclear. Recent progress in computer science, embodied by intelligent agents such as Siri, inspires an approach for moving from networks to multiscale models able to predict a range of cellular phenotypes ...
A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.
...Published in Cell Reports
Efficient repair of UV-induced DNA damage requires the precise coordination of nucleotide excision repair (NER) with numerous other biological processes. To map this crosstalk, we generated a differential genetic interaction map centered on quantitative growth measurements of >45,000 double mutants before and after different doses of UV radiation. ...
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