Ali Amara
Chef d'équipe, Biologie cellulaire des virus émergeants
Institution:
USPC - SET - SVS
Summary
Published articles Show More
Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antivi...
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Published in mBio
The live attenuated yellow fever virus (YFV) vaccine 17D stands as a "gold standard" for a successful vaccine. 17D was developed empirically by passaging the wild-type Asibi strain in mouse and chicken embryo tissues. Despite its immense success, the molecular determinants for virulence attenuation and immunogenicity of the 17D vaccine are poorly u...
The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection.
Published in Journal of Virology
Dengue virus (DENV) is the etiological agent of the major human arboviral disease. We previously demonstrated that the TIM and TAM families of phosphatidylserine (PtdSer) receptors involved in the phagocytosis of apoptotic cells mediate DENV entry into target cells. We show here that human CD300a, a recently identified phospholipid receptor, also b...
Viral apoptotic mimicry.
Published in Nature Reviews Microbiology
As opportunistic pathogens, viruses have evolved many elegant strategies to manipulate host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the exposure of phosphatidylserine - a marker for apoptosis - on the pathogen surface, is emerging as a common theme used by enveloped viruses to promote infection. Focusing on t...
Books Show More
The C type lectins DC-SIGN and L-SIGN: receptors for viral glycoproteins.
Published in Methods in Molecular Biology
DC-SIGN and L-SIGN are C-type lectins that recognize carbohydrate structures present on viral glycoproteins and function as attachment factors for several enveloped viruses. DC-SIGN and L-SIGN enhance viral entry and facilitate infection of cells that express the cognate entry receptor (cis-infection). They are also able to capture viruses and tran...
Theses Show More
Bases moléculaires et cellulaires de l'entrée du virus de la fièvre jaune dans les cellules cibles
Cette travail a eu pour but caractériser les mécanismes moléculaires et cellulaires utilisés par le virus de la fièvre jaune (YFV) pour pénétrer dans les cellules de mammifères. La souche vaccinale contre la fièvre jaune 17D est un virus vivant atténue généré après de nombreux passages de la souche virulente Asibi sur tissus de poulet. Nous montron...
Experience
Chef d'équipe Since 2010
Université Paris Diderot
Biologie cellulaire des virus émergeants; U944/UMR7212, Pathologie et Virologie Moléculaire; Institut Universitaire d'Hématologie (IUH)
