Summary
Published articles Show More
Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea
Published in Journal of Neuroscience
Mammalian Piezo2 channels are essential for transduction of innocuous mechanical forces by proprioceptors and cutaneous touch receptors. In contrast, mechanical responses of somatosensory nociceptor neurons evoking pain, remain intact or are only partially reduced in Piezo2-deficient mice. In the eye cornea, comparatively low mechanical forces are ...
The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels
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Published in Journal of Neuroscience
TRPM8 is a polymodal, nonselective cation channel activated by cold temperature and cooling agents that plays a critical role in the detection of environmental cold. We found that TRPM8 is a pharmacological target of tacrolimus (FK506), a macrolide immunosuppressant with several clinical uses, including the treatment of organ rejection following tr...
GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+
channels
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Published in Physiological Reports
