C, Sekirnjak Lh, Jepson P, Hottowy Alexander Sher W, Dabrowski Alan Litke Ej, Chichilnisky
Published in
Journal of Neurophysiology
Retinitis pigmentosa (RP) is a leading cause of degenerative vision loss, yet its progressive effects on visual signals transmitted from the retina to the brain are not well understood. The transgenic P23H rat is a valuable model of human autosomal dominant RP, exhibiting extensive similarities to the human disease pathology, time course, and elect...
Ta, Szuts V, Fadeyev S, Kachiguine Alexander Sher Mv, Grivich M, Agrochão P, Hottowy W, Dabrowski Ev, Lubenov Ag, Siapas
...
Published in
Nature Neuroscience
Conventional neural recording systems restrict behavioral experiments to a flat indoor environment compatible with the cable that tethers the subject to recording instruments. To overcome these constraints, we developed a wireless multi-channel system for recording neural signals from rats. The device takes up to 64 voltage signals from implanted e...
Gd, Field M, Greschner Jl, Gauthier C, Rangel J, Shlens Alexander Sher Dw, Marshak Alan Litke Ej, Chichilnisky
Published in
Nature Neuroscience
Small bistratified cells (SBCs) in the primate retina carry a major blue-yellow opponent signal to the brain. We found that SBCs also carry signals from rod photoreceptors, with the same sign as S cone input. SBCs exhibited robust responses under low scotopic conditions. Physiological and anatomical experiments indicated that this rod input arose f...
