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Published in Journal of Experimental Medicine
Epstein-Barr virus (EBV) infection in humans is a major trigger of malignant and nonmalignant B cell proliferations. CD27 is a co-stimulatory molecule of T cells, and inherited CD27 deficiency is characterized by high susceptibility to EBV infection, though the underlying pathological mechanisms have not yet been identified. In this study, we repor...
Published in Journal of Allergy and Clinical Immunology
Background: Primary immunodeficiencies (PIDs) are inherited diseases associated with a considerable increase in susceptibility to infections. It is known that PIDs can also predispose to cancer and immune diseases, including allergy, autoimmunity, and inflammation. Objective: We aimed at determining the incidence of autoimmunity and inflammation...
Published in Journal of Allergy and Clinical Immunology
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in PIK3CD, the gene encoding the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ). Objective We sought to review the clinical, immunologic, histopathologic, and radiologic features o...
Published in Clinical Immunology
Published in The Journal of antimicrobial chemotherapy
Published in The New England Journal of Medicine and Surgery and the Collateral Branches of Science
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UMR_S 1163, IHU IMAGINE, Institut des maladies génétiques