Alain Fischer
Directeur de l'unité, UMR_S 1163, IHU IMAGINE, Institut des maladies génétiques
Institution:
USPC - SET - SVS
Summary
Published articles Show More
Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus ...
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Published in Journal of Experimental Medicine
Epstein-Barr virus (EBV) infection in humans is a major trigger of malignant and nonmalignant B cell proliferations. CD27 is a co-stimulatory molecule of T cells, and inherited CD27 deficiency is characterized by high susceptibility to EBV infection, though the underlying pathological mechanisms have not yet been identified. In this study, we repor...
Autoimmune and inflammatory manifestations occur frequently in primary immunodeficiencies
Published in Journal of Allergy and Clinical Immunology
Background: Primary immunodeficiencies (PIDs) are inherited diseases associated with a considerable increase in susceptibility to infections. It is known that PIDs can also predispose to cancer and immune diseases, including allergy, autoimmunity, and inflammation. Objective: We aimed at determining the incidence of autoimmunity and inflammation...
Clinical spectrum and features of activated phosphoinositide 3-kinase delta syndrome: A large patient cohort study
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Published in Journal of Allergy and Clinical Immunology
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in PIK3CD, the gene encoding the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ). Objective We sought to review the clinical, immunologic, histopathologic, and radiologic features o...
Books Show More
Key Concepts
Published in Clinical Immunology
Strategies for Retrovirus-Based Correction of Severe, Combined Immunodeficiency (SCID)
Published in The Journal of antimicrobial chemotherapy
Pathophysiology of B‐Cell Intrinsic Immunoglobulin Class Switch Recombination Deficiencies
Published in The New England Journal of Medicine and Surgery and the Collateral Branches of Science
Theses Show More
Experience
Directeur de l'unité
université Paris Descartes
UMR_S 1163, IHU IMAGINE, Institut des maladies génétiques
