My lab works on molecular mechanisms of cognitive dysfunction in neurodegenerative disorders. We are particularly interested in the relationship between Down syndrome and Alzheimer's disease.
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Ahmad Salehi
Clinical Professor, Stanford Medical School
Palo Alto, United States
https://www.mysciencework.com/profile/ahmad.salehi
Summary
Published articles Show More
Physical exercise induces structural alterations in the hippocampal astrocytes: exploring the role of BDNF-TrkB signalin...
Published in Brain Structure and Function
While it has been known that physical activity can improve cognitive function and protect against neurodegeneration, the underlying mechanisms for these protective effects are yet to be fully elucidated. There is a large body of evidence indicating that physical exercise improves neurogenesis and maintenance of neurons. Yet, its possible effects on...
Noradrenergic System in Down Syndrome and Alzheimer's Disease A Target for Therapy
Published in Current Alzheimer Research
Locus coeruleus (LC) neurons in the brainstem send extensive noradrenergic (NE)-ergic terminals to the majority of brain regions, particularly those involved in cognitive function. Both Alzheimer’s disease (AD) and Down syndrome (DS) are characterized by similar pathology including significant LC degeneration and dysfunction of the NE-ergic system....
Increased incidence of intermittent hypoxemia in the Ts65Dn mouse model of Down syndrome
Published in Neuroscience Letters
In addition to nervous system, cardiovascular and respiratory systems are primarily affected in Down syndrome (DS). The Ts65Dn mouse model is widely used to recapitulate cognitive dysfunction in DS. While these mice consistently show failure in learning and memory along with functional and structural abnormalities in the hippocampal region, the und...
Books Show More
common pathogenic mechanisms between Down syndrome and Alzheimer's diseasae: steps towards therapy
Down syndrome is a chromosomal disorder affecting more than 5.8 million individuals worldwide. Down syndrome can be viewed as a complex multi-system disorder as it manifests into significant physical, psychological, and cognitive abnormalities in affected persons. With aging, most adults with Down syndrome develop the clinical and neuropathological...
