During my PhD at MIT, I used mouse models to study crosstalk between E2F and p19ARF/p53 in the regulation of the cell cycle and tumorigenesis. My current interest is in using mass spectrometry based proteomics to understand the cellular response to cancer therapeutics.
Aaron Aslanian
Staff Researcher
Institution:
Hunter Lab
La Jolla, CA, United States
https://www.mysciencework.com/profile/aaron.aslanian
Summary
Published articles Show More
Escargot restricts niche cell to stem cell conversion in the Drosophila testis.
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Published in Cell Reports
Stem cells reside within specialized microenvironments, or niches, that control many aspects of stem cell behavior. Somatic hub cells in the Drosophila testis regulate the behavior of cyst stem cells (CySCs) and germline stem cells (GSCs) and are a primary component of the testis stem cell niche. The shutoff (shof) mutation, characterized by premat...
Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark target...
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Published in Molecular Cell
Viral hijacking of cellular processes relies on the ability to mimic the structure or function of cellular proteins. Many viruses encode ubiquitin ligases to facilitate infection, although the mechanisms by which they select their substrates are often unknown. The Herpes Simplex Virus type-1-encoded E3 ubiquitin ligase, ICP0, promotes infection thr...
Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression.
Published in Molecular and Cellular Biology
The reversible nature of protein phosphorylation dictates that any protein kinase activity must be counteracted by protein phosphatase activity. How phosphatases target specific phosphoprotein substrates and reverse the action of kinases, however, is poorly understood in a biological context. We address this question by elucidating a novel function...
