Agent
Klauber & Jackson
Grantee
The Rockefeller University
Primary examiner
Sally P. Teng
Application number
8509174
Kind
A
Document number
5854045
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Transmembrane tyrosine phosphatase and methods of use thereof

5854045 - 8509174 - USPTO

Application May 02, 1997 - Publication Dec 29, 1998

Kathy S. Fang Hidesaburo Hanafusa

Abstract

The present invention relates to regulation and control of cellular processes by transmembrane protein tyrosine phosphatases, and to ligands that agonize or antagonize tyrosine phosphorylation mediated by such tyrosine phosphatases. This invention further relates to diagnosis and therapy based on the activity of such ligands. In particular, the invention provides a novel transmembrane protein tyrosine phosphatase-.lambda. (PTP.lambda.), nucleic acids encoding the same, antibodies to the PTP.lambda., and methods for identifying ligands to the PTP.lambda. of the invention. A specific Example describes the isolation and characterization of the first chicken transmembrane PTP, called ChPTP.lambda.. It has a unique extracellular domain containing a Ser/Thr/Pro-rich region, spectrin-like repeats, a fibronectin III domain, and an alternatively spliced N-terminus. The expression of ChPTP.lambda. in various tissues and cells was also examined. ChPTP.lambda. was shown to have a tyrosine-specific phosphatase activity, and the basic characteristics of this enzyme were studied.

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