Applicant
GeneWeave Biosciences, Inc.
Grantee
GeneWeave Biosciences, Inc.
Primary examiner
Christopher M Babic
Primary examiner
Kimberly A. Aron
Application number
15388750
Kind
B2
Document number
10240212
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Systems and Methods for Detection of Cells Using Engineered Transduction Particles

10240212 - 15388750 - USPTO

Application Dec 22, 2016 - Publication Mar 26, 2019

Diego Ariel Rey Shaunak Roy Leonardo Maestri Teixeira Ryan C. Griswold Kenneth G. Olson Bruce J. Richardson Victor H. Yee Werner Frei

Abstract

Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

Description

Claims

Other sources for this patent

  • System and Methods for Detection of Cells Using Engineered Transduction Particles

    20170152576 - 15388750 - USPTO

    Application Dec 22, 2016 - Publication Jun 01, 2017

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