Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them
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Applicant
Inc. Merck & Co.
Representative
Rudolf Emil Ernst et al Blum
Application number
EP78100095A1
Kind
A1
Document number
0000053
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Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them

0000053 - EP78100095A1 - EPO

Application Jun 06, 1978 - Publication Dec 20, 1978

Daniel Frank Veber

Abstract

Somatostatin analogs having the structural formula:whereinA is Phe, Tyr, 0-Me-Tyr,B is Phe, Tyr,C is Thr, Val,wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These peptides have the property of inhibiting release of insulin, inhibiting growth hormone release and inhibiting glucagon release in humans and animals without materially affecting gastric secretion.

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