REAGENT AND METHOD FOR REPAIRING FBN1T7498C MUTATION USING BASE EDITING
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Applicant
Shanghaitech University
Representative
Cabinet Beau de Loménie
Application number
EP18889963A1
Kind
A1
Document number
3816296
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REAGENT AND METHOD FOR REPAIRING FBN1T7498C MUTATION USING BASE EDITING

3816296 - EP18889963A1 - EPO

Application Jul 25, 2018 - Publication May 05, 2021

Xingxu HUANG Guanglei LI Jianan LI

Abstract

The present invention provides a reagent and a method for repairing anFBN1T7498Cmutation by using base editing. A kit for efficiently repairing theFBN1T7498Cmutation is characterized by comprising a base editor and a repair re-sgRNA directed to theFBN1T7498Csite. In the present invention, a base editing technology is used to repair the mutation ofFBN1T7498Cthrough a precise CT single base mutation, thereby providing an efficient and safe method for treating a Marfan syndrome caused by such mutation.

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