DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN
Download Read
Applicant
The Board of Trustees of the University of Arkansas
Applicant
The Kitasato Institute
Applicant
Montefiore Medical Center
Applicant
National University Corporation Kagawa University
Representative
Mewburn Ellis LLP
Application number
EP24153256A3
Kind
A3
Document number
4397755
Shortcuts
→Abstract

Classifications

DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN

4397755 - EP24153256A3 - EPO

Application Dec 14, 2012 - Publication Jan 01, 2025

Joshua SAKON Theresa Leena PHILOMINATHAN SAGAYA Ranjitha KATIKANENI Osama MATSUSHITA Tulasi PONNAPAKKAM Takaki KOIDE Robert C. GENSURE Nozomu NISHI

Abstract

Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

Back to top

Statistics

Seen <100 times
Downloaded <100 times