Applicant
IDENIX PHARMACEUTICALS LLC
Applicant
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Applicant
UNIVERSITE DE MONTPELLIER
Grantee
IDENIX PHARMACEUTICALS LLC
Grantee
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Grantee
UNIVERSITE DE MONTPELLIER
Primary examiner
Traviss C McIntosh, III
Application number
14954815
Kind
B2
Document number
10238680
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D-Amino Acid Phosphoramidate Pronucleotides of Halogeno Pyrimidine Compounds for Liver Disease

10238680 - 14954815 - USPTO

Application Nov 30, 2015 - Publication Mar 26, 2019

Benjamin Alexander Mayes Adel M. Moussa Cyril B. Dousson Gilles Gosselin Claire Pierra David Dukhan

Abstract

Provided herein are compounds, compositions, and methods for the treatment of viral infections, for example, Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are D-amino acid phosphoramidate halogeno pyrimidine nucleoside analog compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula I:




or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein: PD, X, R¹, R², RA, and RB are as described herein.

Description

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