Science Pops Open, Ep. 4: Disrupting the Sleeping Sickness Sym...

A treatment that killed 10% of patients would certainly be considered unacceptable by modern medical standards. And yet, that is the best that doctors can currently offer victims of sleeping sickness. This disease, which strikes rural Africa, in particular, is caused by a parasite called trypanosome. It is passed to a human or animal by the bite of a tsetse fly, much like mosquitoes may transmit the parasite causing malaria. Once in a person’s blood, it travels to the brain where it interrupts the usual sleep/wake cycles. Victims are neither fully conscious nor fully asleep and, without today’s very aggressive drugs, the patient will die.

Cet article existe également en français : Science Pops Open, Ep. 4 : La maladie du sommeil : une symphonie à interrompre

Fabien Guegan believes the parasite’s complex life cycle holds the key to halting sleeping sickness. Between the tsetse fly’s stomach and a person’s blood, trypanosome inhabits two very different environments. Yet, very quickly, it is able to adapt, changing its shape and metabolism by activating different genes. Dr. Guegan is hot on the trail of the molecules he thinks may act as “orchestra conductors”, synchronizing the many different elements of this transformation. Disrupting the conductor could make the whole trypanosome symphony fall apart. His strategy of targeting the transmission process inside the parasite could make it possible to block the spread between infected humans and animals and more tsetse flies. If so, this could mean a huge step forward in controlling sleeping sickness.

In this video, Dr. Guegan explains more about sleeping sickness and trypanosome, and how, if successful, his molecules could provide the best hope yet for blocking the spread of this terrible disease:

Next Monday:

Social welfare is, at once, vitally important and rife with challenges. As governments tighten their budgets, welfare policies are frequently called into question. By studying what happens to society when the State allocates welfare benefits, correctly, to those unable to work, but sometimes incorrectly, too, Sean Slack aims to help governments optimize the aid they bring their citizens.