Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ
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Functional Water Dynamics in Rhodopsin Using Solid-State Deuterium NMR Spectroscopy
Published in The FASEB Journal
G‐protein‐coupled receptors (GPCRs) are the largest family of cell membrane‐bound proteins that detect extracellular stimuli and transduce signals to activate intracellular functions. Drugs that target GPCRs also account for about 27% of the global market share of therapeutic drugs, with aggregated sales for 2011–2015 of ca. US $890 billion [1]. Hy...
Hydration Modulates G-Protein-Coupled Receptor Signaling
...Published in The FASEB Journal
Rhodopsin is the G‐protein‐coupled receptor (GPCR) responsible for scotopic vision in the retina. Up to this point, the role of water in the activation of GPCRs has remained largely unknown. Recently, however, nanosecond molecular dynamics simulations have revealed an influx of bulk water into rhodopsin during activation [1]. Utilizing rhodopsin as...
