Department of Chemical and Biomolecular Engineering Department, Center for Neutron Science, Un
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Preservative Induced Polysorbate 80 Micelle Aggregation.
Published in Journal of Pharmaceutical Sciences
Small angle neutron scattering (SANS) studies of a model pharmaceutical formulation reveal how formulation stability depends on the compatibility of individual components. Solutions of two common protein formulation excipients, polysorbate 80 (PS80), a nonionic surfactant that prevents aggregation, and m-cresol, an antimicrobial agent for multi-dos...