Department Biomedical Sciences and CNR Institute of Neuroscience, University of Padua, Via G. Colombo, 3, 35121 Padua, Italy

High content analysis of γ-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzh...

Published in Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

γ-Secretase mediates the intramembranous proteolysis of amyloid precursor protein (APP), Notch and other cellular substrates and is considered a prime pharmacological target in the development of therapeutics for Alzheimer's disease (AD). We describe here an efficient, new, simple, sensitive and rapid assay to quantify γ-secretase activity in livin...