Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.

Spatial scaling in multiscale models: methods for coupling agent-based and finite-element models of wound healing.

Published in Biomechanics and Modeling in Mechanobiology

Multiscale models that couple agent-based modeling (ABM) and finite-element modeling (FEM) allow the dynamic simulation of tissue remodeling and wound healing, with mechanical environment influencing cellular behaviors even as tissue remodeling modifies mechanics. One of the challenges in coupling ABM to FEM is that these two domains typically empl...