Department of Biology, School of Medicine, University of Zagreb, Zagreb, Croatia.

Methylation-associated silencing of SFRP1 gene in high-grade serous ovarian carcinomas.

Published in Annals of diagnostic pathology

Wnt is a highly conserved signaling pathway responsible for tissue regeneration, maintenance and differentiation of stem cells in adults. Its aberrant activation through reduced expression of Wnt signaling pathway inhibitors, such as proteins from the SFRP family, is commonly seen in many tumors. In the present study we explored SFRP1 protein expre...