Department of Biological Sciences, Purdue University,

Alpha-Synuclein is a Target of Fic-mediated Adenylylation/AMPylation: Possible Implications for Parkinson’s Disease

Published in Journal of Molecular Biology

During disease, cells experience various stresses that manifest as an accumulation of misfolded proteins and eventually lead to cell death. To combat this stress, cells activate a pathway called UPR (Unfolded Protein Response) that functions to maintain ER (endoplasmic reticulum) homeostasis and determines cell fate. We recently reported a hitherto...