Department of Biological Sciences, Columbia University, USA

Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome i...

Published in Nucleic Acids Research

The postreplication repair gene, HLTF , is often amplified and overexpressed in cancer. Here we model HLTF dysregulation through the functionally conserved Saccharomyces cerevisiae ortholog, RAD5 . Genetic interaction profiling and landscape enrichment analysis of RAD5 overexpression ( RAD5 OE ) reveals requirements for genes involved in recombinat...