Department of Biological Science, Florida State University, 91 Chieftain Way, Tallahassee, FL 32306, USA; Institute of Molecular Biophysics, Florida State University, 91 Chieftain Way, Tallahassee, FL 32306, USA.

Domain crossover in the reductase subunit of NADPH-dependent assimilatory sulfite reductase.

Published in Journal of Structural Biology

NADPH-dependent assimilatory sulfite reductase (SiR) from Escherichia coli performs a six-electron reduction of sulfite to the bioavailable sulfide. SiR is composed of a flavoprotein (SiRFP) reductase subunit and a hemoprotein (SiRHP) oxidase subunit. There is no known high-resolution structure of SiR or SiRFP, thus we do not yet fully understand h...