Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA.
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Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment.
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Published in Nature Communications
The inbred mouse strain C57BL/6J is widely used in models of immunological and infectious diseases. Here we show that C57BL/6J mice have a defect in neutrophil recruitment to a range of inflammatory stimuli compared with the related C57BL/6N substrain. This immune perturbation is associated with a missense mutation in Nlrp12 in C57BL/6J mice. Both ...