Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts, USA.

Characterization of CaMKIIα holoenzyme stability.

Published in Protein Science

Ca2+ /calmodulin-dependent protein kinase II (CaMKII) is a Ser/Thr kinase necessary for long-term memory formation and other Ca2+ -dependent signaling cascades such as fertilization. Here, we investigated the stability of CaMKIIα using a combination of differential scanning calorimetry (DSC), X-ray crystallography, and mass photometry (MP). The kin...