CNRS, UMR6097/Université de Nice Sophia Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease

Published in Neurogenetics

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of Lewy bodies. Alpha-synuclein and its interactor synphilin-1 are major components of these inclusions. Rare mutations in the α-synuclein and synphilin-1 genes have been implicated in the pathogenesis of PD; however, t...