CNRS, ISV, UPR2355, Gif-sur-Yvette, France

Trapping conformational states along ligand-binding dynamics of peptide deformylase: the impact of induced fit on enzyme...

Published in PLoS Biology

For several decades, molecular recognition has been considered one of the most fundamental processes in biochemistry. For enzymes, substrate binding is often coupled to conformational changes that alter the local environment of the active site to align the reactive groups for efficient catalysis and to reach the transition state. Adaptive substrate...