Chinese Academy of Medical Sciences & Peking Union Medical College, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing, 100005, China

Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence

Published in Science China Life Sciences

The rapidly increasing prevalence of diabetes mellitus worldwide is one of the most serious and challenging health problems in the 21st century. Mammalian sirtuin 1 (SIRT1) has been shown to decrease high-glucose-induced endothelial cell senescence in vitro and prevent hyperglycemia-induced vascular dysfunction. However, a role for SIRT1 in prevent...