OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynt...
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Published in Leukemia
Effective treatment of some types of cancer can be achieved by modulating cell lineage-specific rather than tumor-specific targets. We conducted a systematic search for novel agents selectively toxic to cells of hematopoietic origin. Chemical library screenings followed by hit-to-lead optimization identified OT-82, a small molecule with strong effi...
