Center for Cell Circuits, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.

Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune...

Published in Human Molecular Genetics

FCGR2A binds antibody-antigen complexes to regulate the abundance of circulating and deposited complexes along with downstream immune and autoimmune responses. Although the abundance of FCRG2A may be critical in immune-mediated diseases, little is known about whether its surface expression is regulated through cis genomic elements and non-coding va...