CEA, Service de Pharmacologie et d'Immunologie, 91191 Gif-sur-Yvette, France

Detection of Functional Ricin by Immunoaffinity and Liquid Chromatography−Tandem Mass Spectrometry

Published in Analytical Chemistry

The toxin ricin is a biological weapon that may be used for bioterrorist purposes. As a member of the group of ribosome-inactivating proteins (RIPs), ricin has an A-chain possessing N-glycosidase activity which irreversibly inhibits protein synthesis. In this paper, we demonstrate that provided appropriate sample preparation is used, this enzymatic...