Case Western Reserve University, Cleveland, OH, USA

Characterization of pathological thyroid tissue using polarization-sensitive second harmonic generation microscopy

Published in Laboratory Investigation

Polarization-second harmonic microscopy was utilized to investigate whether collagen ultrastructure in thyroid due to four carcinoma types and Graves’ disease could be differentiated in human histopathology samples. Three parameters were extracted, revealing that the degree of linear polarization and χ(2)zzz/χ(2)zxx were effective in differentiatin...