Biomedical Neuroscience Institute, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile; Neurounion Biomedical Foundation, Santiago, Chile; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA.

Addicted to secrete - novel concepts and targets in cancer therapy.

Published in Trends in molecular medicine

The unfolded protein response (UPR) mediates the adaptation of the secretory pathway (SP) to fluctuations in cellular protein demand or to environmental variations. Recently, drug screenings have confirmed the therapeutic potential of targeting the UPR in cancer models. However, the UPR may not be the only druggable target of the SP. Moreover, rece...