a Bioinformatics Center, College of Life Sciences, Northwest A & F University , Yangling , Shaanxi , China.

Pred-binding: large-scale protein-ligand binding affinity prediction.

Published in Journal of Enzyme Inhibition and Medicinal Chemistry

Drug target interactions (DTIs) are crucial in pharmacology and drug discovery. Presently, experimental determination of compound-protein interactions remains challenging because of funding investment and difficulties of purifying proteins. In this study, we proposed two in silico models based on support vector machine (SVM) and random forest (RF),...