BeiGene, San Mateo, CA, USA.
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High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.
...Published in Nature medicine
Accurate identification of tumor-derived somatic variants in plasma circulating cell-free DNA (cfDNA) requires understanding of the various biological compartments contributing to the cfDNA pool. We sought to define the technical feasibility of a high-intensity sequencing assay of cfDNA and matched white blood cell DNA covering a large genomic regi...