Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America; Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America.

In silico modeling of human α2C-adrenoreceptor interaction with filamin-2.

Published in PLoS ONE

Vascular smooth muscle α2C-adrenoceptors (α2C-ARs) mediate vasoconstriction of small blood vessels, especially arterioles. Studies of endogenous receptors in human arteriolar smooth muscle cells (referred to as microVSM) and transiently transfected receptors in heterologous HEK293 cells show that the α2C-ARs are perinuclear receptors that transloca...