BASE Initiative, Betty Irene Moore Children’s Heart Center, Lucile Packard Children’s Hospital, Stanford University School of Medicine, Stanford, CA

Genome-wide enhancer maps link risk variants to disease genes

Published in Nature

Genome-wide association studies (GWAS) have now identified thousands of noncoding loci associated with human diseases and complex traits, each of which could reveal insights into biological mechanisms of disease 1 . Many of the underlying causal variants are thought to affect enhancers 2 , 3 , but we have lacked accurate maps of enhancers and their...