Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.

Genome-wide enhancer maps link risk variants to disease genes.

Published in Nature

Genome-wide association studies (GWAS) have identified thousands of noncoding loci that are associated with human diseases and complex traits, each of which could reveal insights into the mechanisms of disease1. Many of the underlying causal variants may affect enhancers2,3, but we lack accurate maps of enhancers and their target genes to interpret...