Advanced Environmental Researches Laboratory, 4 Oituz, Timisoara, 300086, Romania

Computational analysis of protein-protein interfaces involving an alpha helix: insights for terphenyl--like molecules bi...

Published in BMC Pharmacology and Toxicology

BACKGROUND: Protein-Protein Interactions (PPIs) are key for many cellular processes. The characterization of PPI interfaces and the prediction of putative ligand binding sites and hot spot residues are essential to design efficient small-molecule modulators of PPI. Terphenyl and its derivatives are small organic molecules known to mimic one face of...