Publications - 302 Hospital of PLA, Beijing, China

BackgroundEndoscopic biliary stenting by endoscopic retrograde cholangiopancreatography ERCP is the most common form of palliation for malignant hilar obstruction However ERCP in such cases is associated with a risk of cholangitis The incidence of post-ERCP cholangitis is particularly high in Bismuth type IV hilar obstruction and this risk is further increased when the contrast injected for cholangiography is not drained The present study aims to compare the incidence of cholangitis associated with the use of a contrast agent air and CO2 for cholangiography in type IV hilar biliary lesions MethodsThe clinical data of consecutive 70 patients with type IV hilar obstruction who underwent ERCP from October 2013 to November 2017 were retrospectively analyzed These patients were divided into three groups based on the agent used for cholangiography group A contrast n 22 group B air n 18 group C CO2 n 30 These three methods of cholangiography were chronologically separated Prior to the ERCP MRCP was obtained from all patients to guide the endoscopic intervention ResultsAt baseline there was no significant difference in terms of the patient s age gender symptoms and liver function tests among the three groups P 0 05 The complication rates were significantly higher in group A than in groups B and C 63 6 vs 26 7 and 27 8 P 0 05 The incidence of post-ERCP cholangitis was significantly higher in group A P 0 05 while the incidence of post-ERCP pancreatitis and bleeding were similar in the three groups After the ERCP the mean hospital stay was shorter in groups B and C when compared to group A P 0 05 However there was no significant difference in the 30-day mortality rate among the three groups P 0 05 Furthermore there was no significant difference between groups B and C in terms of primary end points ConclusionCO2 or air cholangiography during ERCP for type IV hilar obstruction is associated with reduced risk of post-ERCP cholangitis when compared to conventional contrast agents

CO2 or air cholangiography reduces the risk of post-ERCP cholangitis in patients with Bismuth type IV hilar biliary obst...