1 Department of Neurotrauma, Naval Medical Research Center , Operational and Undersea Medicine Directorate, Silver Spring, Maryland.

Cerebral Vasoactivity and Oxygenation with Oxygen Carrier M101 in Rats.

Published in Journal of Neurotrauma

The severity of traumatic brain injury (TBI) may be reduced if oxygen can be rapidly provided to the injured brain. This study evaluated if the oxygen-carrier M101 causes vasoconstricton of pial vasculature in healthy rats (Experiment 1) and if M101 improves brain tissue oxygen (PbtO2) in rats with controlled cortical impact (CCI)-TBI (Experiment 2...