Ancelin, Marie-Laure Carriere, Isabelle Artero, Sylvaine Maller, Jerome J Meslin, Chantal Dupuy, Anne-Marie Ritchie, Karen Ryan, Joanne Chaudieu, Isabelle
Published in
European Journal of Psychotraumatology
Background : Findings on structural brain alterations following trauma are inconsistent due probably to heterogeneity in imaging studies and population, clinical presentations, genetic vulnerability, and selection of controls. This study examines whether trauma and re-experiencing symptoms are associated with specific alterations in grey matter vol...
Tchakarska, Guergana Sola, Brigitte
The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression. When deregulated (overexpressed, accumulated, inappropriately located), cyclin D1 becomes an on...
Ramondenc, Simon Eveillard, Damien Guidi, Lionel Lombard, Fabien Delahaye, Benoît
Published in
Scientific Reports
While Ocean modeling has made significant advances over the last decade, its complex biological component is still oversimplified. In particular, modeling organisms in the ocean system must integrate parameters to fit both physiological and ecological behaviors that are together very difficult to determine. Such difficulty occurs for modeling Pelag...
Sanchez, Marie-Pierre Guatteo, Raphaël Davergne, Aurore Saout, Judikael Grohs, Cécile Deloche, Marie-Christine Taussat, Sébastien Fritz, Sébastien Boussaha, Mekki Blanquefort, Philippe
...
Published in
Genetics Selection Evolution
BackgroundBovine paratuberculosis is a contagious disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), with adverse effects on animal welfare and serious economic consequences. Published results on host genetic resistance to MAP are inconsistent, mainly because of difficulties in characterizing the infection status of cows. The obj...
Coureux, Pierre-Damien Lazennec-Schurdevin, Christine Bourcier, Sophie Mechulam, Yves Schmitt, Emmanuelle
Published in
Communications Biology
Coureux et al. describe a cryo-EM structure of a 30S initiation complex of Pyrococcus abyssi at 3.2Å resolution. The structure uncovers a novel archaeal ribosomal protein aS21, N-terminal extension of eL41 and brings insights into base modifications of the rRNA.
Diallo, Sileye Mamadou Bogreau, Hervé Papa Mze, Nasserdine Ould Ahmedou Salem, Mohamed Salem Ould Khairy, Mohamed Lemine Parola, Philippe Basco, Leonardo Ould Mohamed Salem Boukhary, Ali
Published in
Infectious Diseases of Poverty
BackgroundPlasmodium falciparum malaria is endemic in the southern sahelian zone of Mauritania where intense internal and trans-border human and livestock movement occurs. The risk of importation and spread of drug-resistant parasites need to be regularly assessed in this region. The objective of the study was to assess the recent malaria situation...
Liu, Yingqi Li, Rui Qiao, Songlin Chen, Xin-xin Deng, Ruiguang Zhang, Gaiping
Published in
Veterinary Research
Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant threat to the global swine industry. Porcine sialoadhesin (poSn) has been previously shown to mediate PRRSV attachment and internalization. In the current study, we report its unidentified role in antagonism of type I interferon (IFN) production during PRRSV infection. We ...
Abdollahi-Arpanahi, Rostam Gianola, Daniel Peñagaricano, Francisco
Published in
Genetics Selection Evolution
BackgroundTransforming large amounts of genomic data into valuable knowledge for predicting complex traits has been an important challenge for animal and plant breeders. Prediction of complex traits has not escaped the current excitement on machine-learning, including interest in deep learning algorithms such as multilayer perceptrons (MLP) and con...
Raymond, Biaty Wientjes, Yvonne C. J. Bouwman, Aniek C. Schrooten, Chris Veerkamp, Roel F.
Published in
Genetics Selection Evolution
BackgroundA multi-population genomic prediction (GP) model in which important pre-selected single nucleotide polymorphisms (SNPs) are differentially weighted (MPMG) has been shown to result in better prediction accuracy than a multi-population, single genomic relationship matrix (GRM\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{was...
Zahra, Mehdi Durand-Zaleski, Isabelle Górecki, Michal Walleser Autiero, Silke Barnett, Gillian Schüpbach, W. M. Michael
Published in
Health and Quality of Life Outcomes
BackgroundA utility value is a health-related quality of life metric (HRQoL) metric used in a cost-effectiveness analysis. While utilities as outcomes in the treatment of advanced Parkinson’s disease (PD) with deep brain stimulation (DBS) are available, they do not currently exist for PD with early motor complications. The objectives of this study ...
