Kim, Dae Hun Kim, Su-Young Huh, Hee Jae Lee, Nam Yong Koh, Won-Jung Jhun, Byung Woo
Published in
Antimicrobial agents and chemotherapy
We evaluated the in vitro activity of rifamycin derivatives, including rifampin, rifapentine, rifaximin, and rifabutin, against clinical nontuberculous mycobacteria (NTM) isolates. Of the rifamycin derivatives, rifabutin showed the lowest MICs against all NTM species, including Mycobacterium avium complex, M. abscessus, and M. kansasii Rifabutin al...
Khan, Ayesha Pettaway, Cedric Dien Bard, Jennifer Arias, Cesar A Bhatti, Micah M Humphries, Romney M
Published in
Antimicrobial agents and chemotherapy
Stenotrophomonas maltophilia are an emerging cause of serious infections with high associated mortality in immunocompromised patients. Treatment of S. maltophilia infections is complicated by intrinsic resistance to many antimicrobials, including carbapenems, aminoglycosides, and some cephalosporins. Despite this, >90% of isolates are susceptible t...
Michaud, Félix Sueur, Jérôme Cesne, Maxime Le Haupert, Sylvain
Open audio databases such as Xeno-Canto are widely used to build datasets to explore bird song repertoire or to train models for automatic bird sound classification by deep learning algorithms. However, such databases suffer from the fact that bird sounds are weakly labelled: a species name is attributed to each audio recording without timestamps t...
Dubey, Vineet Gupta, Rinki Pathania, Ranjana
Published in
Antimicrobial agents and chemotherapy
Bacterial persisters represent non-inheritable drug tolerant population that are linked to recalcitrance of infections in healthcare settings. The rise of antibiotic resistance and depletion of new antibiotics in drug discovery pipeline has made the task of persister eradication more daunting. In the present study, we report that treatment of Acine...
White, Kirsten L Osman, Nathan Cuadra-Foy, Ernesto Brenner, Bluma G Shivakumar, Devleena Campigotto, Federico Tsiang, Manuel Morganelli, Philip A Novikov, Nikolai Lazerwith, Scott E
...
Published in
Antimicrobial agents and chemotherapy
The HIV integrase (IN) strand transfer inhibitor (INSTI) bictegravir (BIC) has a long dissociation half-life (t1/2) from wild-type IN-DNA complexes: BIC 163 hr > dolutegravir (DTG) 96 hr > raltegravir (RAL) 10 hr > elvitegravir (EVG) 3.3 hr. In cells, BIC had more durable antiviral activity against wild-type HIV after drug washout than RAL or EVG. ...
Portillo-Calderón, I Ortiz-Padilla, M de Gregorio-Iaria, B Merino-Bohorquez, V Blázquez, J Rodríguez-Baño, J Rodríguez-Martínez, J M Pascual, A Docobo-Pérez, F
Published in
Antimicrobial agents and chemotherapy
Objectives:To evaluate human-like intravenous doses of fosfomycin (8g/Q8h) and amikacin (15mg/kg/Q24h) efficacy in monotherapy and in combination against six fosfomycin-heteroresistant Escherichia coli isolates using a hollow-fiber infection model (HFIM).Materials and methods:Six fosfomycin-heteroresistant E. coli isolates (4 with strong mutator ph...
Zhao, Yican Cai, Yuying Chen, Zhenghong Li, Huanjie Xu, Zhengzheng Li, Wenjuan Jia, Jihui Sun, Yundong
Published in
Antimicrobial agents and chemotherapy
Recently, there is increased incidence of drug-resistant Helicobacter pylori infection. Biofilm formation confers multidrug resistance to bacteria. Moreover, it has been found that the formation of biofilm on the surface of gastric mucosa is an important reason for the difficulty of eradication of H. pylori The mechanisms underlying H. pylori biofi...
Wu, Wendy Yi-Ying Haider, Zahra Feng, Xiaoshuang Heath, Alicia K Tjønneland, Anne Agudo, Antonio Masala, Giovanna Robbins, Hilary A Huerta, José-María Guevara, Marcela
...
Published in
International journal of cancer
The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the ri...
Fekkar, Arnaud Blaize, Marion Bouglé, Adrien Normand, Anne-Cécile Raoelina, Audrey Kornblum, Dimitri Kamus, Laure Piarroux, Renaud Imbert, Sébastien
Published in
Antimicrobial agents and chemotherapy
The worldwide emergence of multidrug-resistant pathogenic fungi is a threat to human health. At this very moment, an emergence of Candida parapsilosis isolates harbouring a resistance to fluconazole, one of the most popular antifungal drugs, is being described in several countries. We seek to better understanding the epidemiology, pathogenicity and...
Cojutti, Pier Giorgio Rinaldi, Matteo Zamparini, Eleonora Rossi, Nicolò Tedeschi, Sara Conti, Matteo Pea, Federico Viale, Pierluigi
Published in
Antimicrobial agents and chemotherapy
Background: Dalbavancin is gaining interest in the treatment of complex osteoarticular (OA) infections.Objective: To conduct a population pharmacokinetic analysis of dalbavancin in a prospective cohort of adult patients with Gram-positive OA infections and to identify optimal dosing regimens for long term-treatment.Methods: Non-linear mixed-effects...
