Blasdell, Kim R. Davis, Steven S. Voysey, Rhonda Bulach, Dieter M. Middleton, Deborah Williams, Sinead Harmsen, Margaret B. Weir, Richard P. Crameri, Sandra Walsh, Susan J.
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Published in
Veterinary Research
Bovine ephemeral fever is a vector-borne disease of ruminants that occurs in tropical and sub-tropical regions of Africa, Asia and Australia. The disease is caused by a rhabdovirus, bovine ephemeral fever virus (BEFV), which occurs as a single serotype globally. Although several other closely related ephemeroviruses have been isolated from cattle a...
Pham, Thu Thao Ban, Jihye Hong, Yeojin Lee, Jiae Vu, Thi Hao Truong, Anh Duc Lillehoj, Hyun S. Hong, Yeong Ho
Published in
Veterinary Research
MicroRNAs (miRNAs) are small non-coding RNAs that contribute to host immune response as post-transcriptional regulation. The current study investigated the biological role of the chicken (Gallus gallus) microRNA-200a-3p (gga-miR-200a-3p), using 2 necrotic enteritis (NE) afflicted genetically disparate chicken lines, 6.3 and 7.2, as well as the mech...
Gil, Mélodie Reynes, Christelle Cazals, Guillaume Enjalbal, Christine Sabatier, Robert Saucier, Cédric
Published in
Scientific Reports
A rapid Ultra Performance Liquid Chromatography coupled with Quadrupole/Time Of Flight Mass Spectrometry (UPLC-QTOF-MS) method was designed to quickly acquire high-resolution mass spectra metabolomics fingerprints for rosé wines. An original statistical analysis involving ion ratios, discriminant analysis, and genetic algorithm (GA) was then applie...
Dahlet, Thomas Argüeso Lleida, Andrea Al Adhami, Hala Dumas, Michael Bender, Ambre Ngondo, Richard P. Tanguy, Manon Vallet, Judith Auclair, Ghislain Bardet, Anaïs F.
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Published in
Nature Communications
DNA methyltrasferases play important role during mouse embryo development. Here the authors reveal the consequences of genetic inactivation of Dnmt1, Dnmt3a and Dnmt3b on the methylome and transcriptome of mouse embryos genome-wide.
Hozé, Nathanaël Salje, Henrik Rousset, Dominique Fritzell, Camille Vanhomwegen, Jessica Bailly, Sarah Najm, Matthieu Enfissi, Antoine Manuguerra, Jean-Claude Flamand, Claude
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Published in
Nature Communications
Mayaro virus (MAYV) is an emerging arbovirus, but cross-reactivity with other alphaviruses makes analysis of its epidemiology difficult. Here, the authors develop an analytical framework to assess MAYV epidemiology and find evidence for an important sylvatic cycle and seroprevalences of up to 18% in some areas of French Guiana.
Valverde, Sébastien Vandecasteele, Marie Piette, Charlotte Derousseaux, Willy Gangarossa, Giuseppe Aristieta Arbelaiz, Asier Touboul, Jonathan Degos, Bertrand Venance, Laurent
Published in
Nature Communications
Deep brain stimulation (DBS) is a symptomatic treatment of Parkinson’s disease (PD) that benefits only a minority of patients. Here, the authors show that activation of cortical somatostatin interneurons alleviates motor symptoms in a mouse model of PD and may constitute a less invasive alternative than DBS.
Senevirathne, Amal Hewawaduge, Chamith Lee, John Hwa
Published in
Veterinary Research
The present study employs the Brucella abortus L7/L12 antigen in a Salmonella secretion platform and investigates its ability to induce protective immune responses against wild type challenge in BALB/c mice. The highly conserved L7/L12 open reading frame was PCR amplified from B. abortus and cloned into a prokaryotic expression vector, pJHL65, dire...
Andrade, Ricardo Doostmohammadi, Mahdi Santos, João L. Sagot, Marie-France Mira, Nuno P. Vinga, Susana
Published in
BMC Bioinformatics
BackgroundIn this paper, we explore the concept of multi-objective optimization in the field of metabolic engineering when both continuous and integer decision variables are involved in the model. In particular, we propose a multi-objective model that may be used to suggest reaction deletions that maximize and/or minimize several functions simultan...
Lu, Mingmin Tian, Xiaowei Yang, Zhang Wang, Wenjuan Tian, Ai-Ling Li, Charles Yan, Ruofeng Xu, Lixin Song, Xiaokai Li, Xiangrui
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Published in
Veterinary Research
Haemonchus contortus has evolved highly integrated and sophisticated mechanisms to promote coexistence with hosts. The excretory-secretory (ES) products generated by this parasite contribute to the regulation of the host immune response to facilitate immune evasion and induce chronicity, but the proteins responsible for this process and the exact c...
Tang, Wenjie Chen, Daiwen Yu, Bing He, Jun Huang, Zhiqing Zheng, Ping Mao, Xiangbing Luo, Yuheng Luo, Junqiu Wang, Quyuan
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Published in
Veterinary Research
Early weaning-induced stress causes diarrhoea, thereby reducing the growth performance of piglets. Gut bacterial dysbiosis has emerged as a leading cause of post-weaning diarrhoea. The present study aimed to investigate the effect of capsulized faecal microbiota transplantation (FMT) on the gut bacterial community, immune response and gut barrier f...
