Published in Molecular Autism
BackgroundContrasting findings were reported in several animal models with a Shank3 mutation used to induce various autism spectrum disorder (ASD) symptoms. Here, we aimed at investigating behavioral, cellular, and molecular consequences of a C-terminal (frameshift in exon 21) deletion in Shank3 protein in mice, a mutation that is also found in cli...
Published in Renal failure
This study explored whether lipid disorders or an elevated atherogenic index of plasma (AIP, a risk factor for cardiovascular diseases) could predict major kidney function decline. We conducted a retrospective 7-year cohort study of 3712 Chinese adults followed up between 2010 and 2017. Major kidney function decline was defined as a ≥ 30% reduction...
Published in Scientific Reports
Climate simulations often need to be adjusted (i.e., corrected) before any climate change impacts studies. However usual bias correction approaches do not differentiate the bias from the different uncertainties of the climate simulations: scenario uncertainty, model uncertainty and internal variability. In particular, in the case of a multi-run ens...
Published in Scientific Reports
Speaker recognition is characterized by considerable inter-individual variability with poorly understood neural bases. This study was aimed at (1) clarifying the cerebral correlates of speaker recognition in humans, in particular the involvement of prefrontal areas, using multi voxel pattern analysis (MVPA) applied to fMRI data from a relatively la...
Published in Scientific Reports
Bisphenol (BP)A is an endocrine disruptor (ED) widely used in thermal papers. Regulatory restrictions have been established to prevent risks for human health, leading to BPA substitution by structural analogues, like BPS and BPF. We previously demonstrated that oral perinatal exposure to BPA had long-term consequences on immune responses later in l...
Published in Critical Care
Published in Communications Biology
Wang et al. show how genetic sequence and base modifications can be detected simultaneously on single molecules of both DNA and RNA using magnetic tweezers. They also demonstrate an amplification-free CRISPR/Cas9-based strategy for isolating target regions from native DNA and apply this approach to the isolation of targets from E. coli and human ge...
Published in Population Health Metrics
PurposeTo study the trends of smoking-attributable mortality among the low and high educated in consecutive birth cohorts in 11 European countries.MethodsRegister-based mortality data were collected among adults aged 30 to 79 years in 11 European countries between 1971 and 2012. Smoking-attributable deaths were estimated indirectly from lung cancer...
Published in Scientific Reports
Life histories of species may be shaped by nutritional limitations posed on populations. Yet, populations contain individuals that differ according to sex and life stage, each of which having different nutritional demands and experiencing specific limitations. We studied patterns of resource assimilation, allocation and excretion during the growth ...
Published in BMC Bioinformatics
BackgroundMulti-omics experimental approaches are becoming common practice in biological and medical sciences underlining the need to design new integrative techniques and applications to enable the multi-scale characterization of biological systems. The integrative analysis of heterogeneous datasets generally allows to acquire additional insights ...
