Shiriaev, Dmitrii I Sofronova, Alina A Berdnikovich, Ekaterina A Lukianov, Dmitrii A Komarova, Ekaterina S Marina, Valeria I Zakalyukina, Yuliya V Biryukov, Mikhail V Maviza, Tinashe P Ivanenkov, Yan A
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Antimicrobial agents and chemotherapy
Bacterial type II topoisomerases, DNA gyrase and topoisomerase IV, are targets of many antibiotics including fluoroquinolones (FQs). Unfortunately, a number of bacterial species easily acquire resistance to FQs by mutations in either DNA gyrase or topoisomerase IV genes. The emergence of resistant pathogenic strains is a global problem in healthcar...
Gallardo, Alejandro Iglesias, María-Rocío Ugarte-Ruiz, María Hernández, Marta Miguela-Villoldo, Pedro Gutiérrez, Gloria Rodríguez-Lázaro, David Domínguez, Lucas Quesada, Alberto
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Antimicrobial agents and chemotherapy
The use of colistin as a last resort antimicrobial is compromised by the emergence of resistant enterobacteria with acquired determinants like mcr genes, mutations that activate the PmrAB system and by still unknown mechanisms. This work analyzed 74 E. coli isolates from healthy swine, turkey or bovine, characterizing their colistin resistance dete...
Cho, Hye-Kyung Karau, Melissa J Greenwood-Quaintance, Kerryl E Hansford, Karl A Cooper, Matthew A Blaskovich, Mark A T Patel, Robin
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Antimicrobial agents and chemotherapy
MRSA periprosthetic 1 joint infection (PJI) can be challenging to treat due to biofilm formation, alongside sometimes limited vancomycin activity (1-3).…. Copyright © 2021 Cho et al.
Yang, Ling Shi, Haiyang Zhang, Lijuan Lin, Xiaoling Wei, Yinan Jiang, Hongxia Zeng, Zhenling
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Antimicrobial agents and chemotherapy
AcrAB-TolC is a major tripartite multidrug efflux pump conferring resistance to a wide variety of compounds in Gram-negative pathogens. Many AcrB mutants have been constructed through site-directed mutagenesis to probe the mechanism of AcrB function in antibiotic resistance. However, much less is known about the actual drug resistance related mutan...
Si, Yu Zeng, Weilin Li, Na Wang, Chengqi Siddiqui, Faiza Zhang, Jie Pi, Liang He, Xi Zhao, Luyi Wang, Siqi
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Published in
Antimicrobial agents and chemotherapy
Plasmodium falciparum from the Greater Mekong subregion has evolved resistance to the artemisinin-based combination therapy dihydroartemisinin and the partner drug piperaquine. To monitor the potential westward spread or independent evolution of piperaquine resistance, we evaluated the in vitro susceptibility of 120 P. falciparum isolates collected...
Li, Ling Zhang, Mengge Wang, Wenjia Xia, Ruirui Ma, Yanan Wei, Xin Wang, Xinhua Sun, Xiaomin Xie, Xiaohong Xie, Shiling
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Antimicrobial agents and chemotherapy
Two novel ISCR1-associated dfr genes, dfrA42 and dfrA43, were identified from trimethoprim (TMP)-resistant Proteus strains and were shown to confer high level TMP resistance (MIC ≥ 1024 mg/L) when cloned into Escherichia coli These genes were hosted by complex class 1 integrons suggesting their potentials for dissemination. Analysis of enzymatic pa...
Schulthess, Bettina Schäfle, Daniel Kälin, Nicole Widmer, Tamara Sander, Peter
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Antimicrobial agents and chemotherapy
Recent outbreaks of cardiac surgery-associated Mycobacterium chimaera infections have highlighted the importance of species differentiation within the Mycobacterium avium complex and pointed to a lack of antibiotic susceptibility data for M. chimaera Using the MGIT 960/EpiCenter TB eXiST platform, we have determined antibiotic susceptibility patter...
Li, Jizhou Coste, Alix T Liechti, Maroussia Bachmann, Daniel Sanglard, Dominique Lamoth, Frederic
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Antimicrobial agents and chemotherapy
Candida auris is a novel Candida species that has spread in all continents causing nosocomial outbreaks of invasive candidiasis. C. auris has the ability to develop resistance to all antifungal drug classes. Notably, many C. auris isolates are resistant to the azole drug fluconazole, a standard therapy of invasive candidiasis.Azole resistance in C....
Ersoy, Selvi C Chambers, Henry F Proctor, Richard A Rosato, Adriana E Mishra, Nagendra N Xiong, Yan Q Bayer, Arnold S
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Antimicrobial agents and chemotherapy
Certain methicillin-resistant Staphylococcus aureus (MRSA) strains exhibit β-lactam-susceptibility in vitro, ex vivo and in vivo in the presence of NaHCO3 (NaHCO3-responsive MRSA). Herein, we investigate the impact of NaHCO3 on factors required for PBP2a functionality. Prototype NaHCO3-responsive and -nonresponsive MRSA strains (as defined in vitro...
Chen, Chun-Hsien Wang, Yu-Jen Huang, Jian-Ming Huang, Fu-Chin Lin, Wei-Chen
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Antimicrobial agents and chemotherapy
Acanthamoeba spp. are free-living protozoan that cause a serious human eye disease called Acanthamoeba keratitis (AK). Several new and effective medical therapy for AK patients remains highly debated and therefore, CHG is still considered one of the first lines of treatment for AK patients. We hypothesized that ocular microenvironmental factors are...
