Su, Huilin Zhu, Min Tsui, Clement Kin-Ming van der Lee, Henrich Tehupeiory-Kooreman, Marlou Zoll, Jan Engel, Tobias Li, Li Zhu, Junhao Lu, Zihan
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Published in
Antimicrobial agents and chemotherapy
Triazole resistance in A. fumigatus is an increasing worldwide problem that causes major challenges in the management of aspergillosis. New antifungal drugs are needed with novel targets, that are effective in triazole-resistant infection. In this study, we retrospectively evaluated potency of the novel drug olorofim compared to contemporary antifu...
Griffith, David C Morgan, Elizabeth E Dudley, Michael N Loutit, Jeffery S
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Antimicrobial agents and chemotherapy
The pharmacokinetics and safety of biapenem were studied in 36 healthy adult subjects in a randomized, placebo-controlled, double blind, sequential single and multiple-ascending dose study using doses from 250 to 1250 mg administered three times a day using 3-hour infusions. Maximum concentrations for biapenem were achieved at the end of the 3-hour...
Azad, Mohamad A K Zhang, Shuo Li, Jiayao Kim, Yeonuk Yu, Heidi H Fulcher, Alex J Howard, Daryl L de Jonge, Martin D James, Simon A Roberts, Kade D
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Antimicrobial agents and chemotherapy
Intravenous administration of the last-line polymyxins results in poor drug exposure in the lungs and potential nephrotoxicity; while inhalation therapy offers better pharmacokinetics/pharmacodynamics for pulmonary infections by delivering the antibiotic to the infection site directly. However, polymyxin inhalation therapy has not been optimized an...
Simon, Maïa Pereira, Ouarda Guillet-Thibault, Julie Hulscher, Marlies E J L Pulcini, Céline Thilly, Nathalie
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Antimicrobial agents and chemotherapy
Background - The literature shows that the prescription of antibiotics in dental care is often unnecessary or inappropriate. Indicators estimating the appropriateness of antibiotics prescribed by dentists based on routine databases are however not available in the literature. Our objectives were to: (i) design proxy indicators estimating the approp...
Lun, Shichun Xiao, Shiqi Zhang, Wei Wang, Shuangshuang Gunosewoyo, Hendra Yu, Li-Fang Bishai, William R
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Antimicrobial agents and chemotherapy
Polyketide synthase 13 (Pks13) is an important enzyme found in Mycobacterium tuberculosis (M. tuberculosis) that condenses two fatty acyl chains to produce α-alkyl β-ketoesters, which in turn serve as the precursors for the synthesis of mycolic acids that are essential building blocks for maintaining the cell wall integrity of M. tuberculosis Coume...
Nong, Yi Taiaroa, George Pasricha, Shivani Guérillot, Romain Monk, Ian R Baines, Sarah L Carter, Glen P Howden, Benjamin P Williamson, Deborah A
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Antimicrobial agents and chemotherapy
Topical antibiotic preparations, such as fusidic acid (FA) or mupirocin, are used in the prevention and treatment of superficial skin infections caused by staphylococci. Previous genomic epidemiology work has suggested an association between the widespread use of topical antibiotics and the emergence of methicillin resistant Staphylococcus aureus i...
Fen, Shirley Hii Yi Tandhavanant, Sarunporn Phunpang, Rungnapa Ekchariyawat, Peeraya Saiprom, Natnaree Chewapreecha, Claire Seng, Rathanin Thiansukhon, Ekkachai Morakot, Chumpol Sangsa, Narongchai
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Published in
Antimicrobial agents and chemotherapy
Melioidosis is an often fatal infection in tropical regions caused by an environmental bacterium, Burkholderia pseudomallei Current recommended melioidosis treatment requires intravenous β-lactam antibiotics such as ceftazidime (CAZ), meropenem (MEM) or amoxicillin-clavulanic acid (AMC) and oral trimethoprim-sulfamethoxazole. Emerging antibiotic re...
Marin, Adriana A Murillo, Oscar Sussmann, Rodrigo A Ortolan, Luana S Battagello, Daniella S de Castro Quirino, Thatyane Bittencourt, Jackson C Epiphanio, Sabrina Katzin, Alejandro M Carvalho, Leonardo J M
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Published in
Antimicrobial agents and chemotherapy
Cerebral malaria (CM) is a severe immunovasculopathy which presents high mortality rate (15-20%), despite the availability of artemisinin-based therapy. More effective immunomodulatory and/or antiparasitic therapies are urgently needed. Experimental Cerebral Malaria (ECM) in mice is used to elucidate aspects involved in this pathology since manifes...
Yang, Mei Zhao, Libo Wang, Xiaohui Sun, Chen Gao, Hengmiao Wang, Xiaoling Qian, Suyun
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Antimicrobial agents and chemotherapy
Linezolid is an oxazolidinone antibiotic exhibiting efficacy against multidrug-resistant (MDR) Gram-positive-related infections. However, its population pharmacokinetic (PopPK) profile in Chinese critically ill children has not been characterized. Optimal dosing regimens should be established according to the PopPK/pharmacodynamic(PD) properties of...
Ghannoum, M Herrada, J McCormick, Thomas S Long, L
Published in
Antimicrobial agents and chemotherapy
BACKGROUND. Candida auris has demonstrated the ability to colonize the skin of hospitalized patients, possibly contributing to nosocomial spread. OBJECTIVE. The objective was to determine whether two novel transdermal agents could clear skin colonization established by C. auris METHODS. A murine skin colonization model was first optimized and then ...
